MMP8 anticorps (Cleaved-Leu101)

N° du produit ABIN8122805

Cet anticorps Lapin Polyclonal détecte spécifiquement MMP8 dans WB et IHC. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour MMP8 anticorps (Cleaved-Leu101) (ABIN8122805)

Antigène: MMP8 (Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMP8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-MMP8 anticorps

Épitope: Cleaved-Leu101

Fonction: MMP8 (Cleaved-Leu101) Antibody

Specificité: This antibody detects endogenous levels of Human,Mouse,Rat MMP8 (Cleaved-Leu101, protein was cleaved amino acid sequence between 100-101 )

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogène: Synthesized peptide derived from human MMP8 (Cleaved-Leu101)

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur MMP8

Antigène: MMP8 (Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8))

Autre désignation: MMP8

Sujet:

Synonyms: Neutrophil collagenase (EC 3.4.24.34, Matrix metalloproteinase-8, MMP-8, PMNL collagenase, PMNL-CL)

Background: catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 3 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Cannot be activated without removal of the activation peptide.,function:Can degrade fibrillar type I, II, and III collagens.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,subcellular location:Stored in intracellular granules.,tissue specificity:Neutrophils.,

Gene Name: MMP8 CLG1

Protein Name: MMP8 (Cleaved-Leu101)

ID gène: 4317

UniProt: P22894