MLKL anticorps (AA 40-120)

N° du produit ABIN8123027

Cet anticorps Lapin Polyclonal détecte spécifiquement MLKL dans WB et IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour MLKL anticorps (AA 40-120) (ABIN8123027)

Antigène: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MLKL est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-MLKL anticorps

Épitope: AA 40-120

Fonction: MLKL Antibody

Specificité: MLKL Polyclonal Antibody detects endogenous levels of MLKL protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from MLKL . at AA range: 40-120

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur MLKL

Antigène: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Autre désignation: MLKL

Sujet:

Synonyms: MLKL, Mixed lineage kinase domain-like protein

Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],

Gene Name: MLKL

Protein Name: Mixed lineage kinase domain-like protein

ID gène: 197259

UniProt: Q8NB16