PPP1R12A anticorps (pSer507)

N° du produit ABIN8123155

Cet anticorps anti-PPP1R12A Polyclonal Lapin (ABIN8123155) détecte spécifiquement PPP1R12A dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PPP1R12A anticorps (pSer507) (ABIN8123155)

Antigène: PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP1R12A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-PPP1R12A anticorps

Épitope: pSer507

Fonction: MYPT1 (Phospho Ser507) Antibody

Specificité: This antibody detects endogenous levels of Human Mouse Rat MYPT1 (phospho-Ser507)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogène: Synthesized phosho peptide around human MYPT1 (Ser507)

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur PPP1R12A

Antigène: PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))

Autre désignation: MYPT1

Sujet:

Synonyms: Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)

Background: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosph

Gene Name: PPP1R12A MBS MYPT1

Protein Name: MYPT1 (Ser507)

ID gène: 4659

UniProt: O14974

Pathways: M Phase