NPLOC4 anticorps (AA 270-350)

N° du produit ABIN8123420

Cet anticorps Lapin Polyclonal détecte spécifiquement NPLOC4 dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour NPLOC4 anticorps (AA 270-350) (ABIN8123420)

Antigène: NPLOC4 (Nuclear Protein Localization 4 Homolog (NPLOC4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPLOC4 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-NPLOC4 anticorps

Épitope: AA 270-350

Fonction: NPL4 Antibody

Specificité: NPL4 Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human protein . at AA range: 270-350

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur NPLOC4

Antigène: NPLOC4 (Nuclear Protein Localization 4 Homolog (NPLOC4))

Autre désignation: NPL4

Sujet:

Background: domain:Binds ubiquitinated proteins via its RanBP2-type zinc finger.,function:The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope.,pathway:Protein degradation, proteasomal ubiquitin-dependent pathway.,similarity:Belongs to the NPL4 family.,similarity:Contains 1 RanBP2-type zinc finger.,subcellular location:Associated with the endoplasmic reticulum and nuclear.,subunit:Heterodimer with UFD1L. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and inhibits Golgi membrane fusion.,tissue specificity:Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.,

Gene Name: NPLOC4 KIAA1499 NPL4

Protein Name: Nuclear protein localization protein 4 homolog (Protein NPL4)

ID gène: 55666

UniProt: Q8TAT6