PMS2CL/PMS2 anticorps (AA 600-700)

N° du produit ABIN8123821

Cet anticorps anti-PMS2CL/PMS2 Monoclonal Souris (Clone AB2348) (ABIN8123821) détecte spécifiquement PMS2CL/PMS2 dans IHC. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour PMS2CL/PMS2 anticorps (AA 600-700) (ABIN8123821)

Antigène: PMS2CL/PMS2 (PMS2) (PMS1 Homolog 2, Mismatch Repair System Component (PMS2))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PMS2CL/PMS2 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: AB2348

Détail du produit anti-PMS2CL/PMS2 anticorps

Épitope: AA 600-700

Fonction: Postmeiotic Segregation Increased 2 (PMS2) mouse mAb

Specificité: The antibody can specifically recognize human PMS2 protein.

Purification: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogène: A synthetic peptide corresponding to the amino acid region 600 - 700 of the human Postmeiotic Segregation Increased 2 protein.

Isotype: IgG

Information d'application

Indications d'application: IHC, 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at-20°C. Avoid freeze / thaw cycles.

Détails sur PMS2CL/PMS2

Antigène: PMS2CL/PMS2 (PMS2) (PMS1 Homolog 2, Mismatch Repair System Component (PMS2))

Autre désignation: Postmeiotic Segregation Increased 2

Sujet:

Synonyms: DNA mismatch repair gene homologue, DNA mismatch repair protein PMS2, H_DJ0042M02. 9, HNPCC4, Mismatch repair endonuclease PMS2, Mismatch repair gene PMSL2, MLH4, PMS 2, PMS1 homolog 2 mismatch repair system, PMS1 protein homolog 2, PMS2, PMS2 postmeiotic segregation increased 2, PMS2 postmeiotic segregation increased 2 (S. cerevisiae) , PMS2_HUMAN, PMS2CL, PMSL2, Postmeiotic segregation increased, S. cerevisiae, 2

Background: Human mismatch repair genes play an important role in maintaining the integrity and stability of genetic information and avoiding genetic mutation. PMS2 is a mismatch repair protein with a molecular weight of 96 kDa, located on chromosome 7. It mainly corrects single base mismatch and small fragment mismatch in vivo. PMS2 forms heterodimer with MLH1 protein and coordinates the binding of other proteins after being activated by ATP to repair DNA errors during cell division. At present, it is mostly used for Lynch syndrome screening together with MLH1, MSH2 and MSH6.

Gene Name: PMS2

Protein Name: Postmeiotic Segregation Increased 2

ID gène: 5395

UniProt: P54278