SMAD7 anticorps (acLys70)

N° du produit ABIN8124749

Cet anticorps Lapin Polyclonal détecte spécifiquement SMAD7 dans WB et IHC. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SMAD7 anticorps (acLys70) (ABIN8124749)

Antigène: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMAD7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-SMAD7 anticorps

Épitope: acLys70

Fonction: Smad7 (Acetyl Lys70) Antibody

Specificité: This antibody detects endogenous levels of Human,Mouse,Rat Smad7 (Acetyl Lys70)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogène: Synthesized peptide derived from human Smad7 (Acetyl Lys70)

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur SMAD7

Antigène: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Autre désignation: Smad7

Sujet:

Synonyms: Mothers against decapentaplegic homolog 7 (MAD homolog 7, Mothers against DPP homolog 7, Mothers against decapentaplegic homolog 8, MAD homolog 8, Mothers against DPP homolog 8, SMAD family member 7, SMAD 7, Smad7, hSMAD7)

Background: The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],

Gene Name: SMAD7 MADH7 MADH8

Protein Name: Smad7 (Acetyl Lys70)

ID gène: 4092

UniProt: O15105

Pathways: Interferon-gamma Pathway, Cell-Cell Junction Organization