TBC1D4 anticorps (pSer318)

N° du produit ABIN8125127

Cet anticorps Lapin Polyclonal détecte spécifiquement TBC1D4 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TBC1D4 anticorps (pSer318) (ABIN8125127)

Antigène: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBC1D4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TBC1D4 anticorps

Épitope: pSer318

Fonction: AS160 (Phospho Ser318) Antibody

Specificité: This antibody detects endogenous levels of Human AS160 (phospho-Ser318)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogène: Synthesized phosho peptide around human AS160 (Ser318)

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur TBC1D4

Antigène: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Autre désignation: AS160

Sujet:

Synonyms: TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160)

Background: This gene is a member of the Tre-2/BUB2/CDC16 domain family.The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Ph

Gene Name: TBC1D4 AS160 KIAA0603

Protein Name: AS160 (Ser318)

ID gène: 9882

UniProt: O60343