TBCB anticorps

N° du produit ABIN8125428

L’anticorps anti-TBCB Polyclonal Lapin est utilisé pour la détection de TBCB dans des échantillons de Humain et Souris. Il a été validé pour WB et ELISA.

Aperçu rapide pour TBCB anticorps (ABIN8125428)

Antigène: TBCB (Tubulin Folding Cofactor B (TBCB))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBCB est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-TBCB anticorps

Fonction: TBCB Antibody

Specificité: TBCB Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human protein

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur TBCB

Antigène: TBCB (Tubulin Folding Cofactor B (TBCB))

Autre désignation: TBCB

Sujet:

Background: function:Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth.,PTM:Phosphorylation by PAK1 is required for normal function. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome.,similarity:Belongs to the TBCB family.,similarity:Contains 1 CAP-Gly domain.,subcellular location:Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.,subunit:Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex, interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cofactors B and E can form a heterodimer which binds to alpha-tubulin and enhances their ability to dissociate tubulin heterodimers. Binds to GAN.,tissue specificity:Found in most tissues.,

Gene Name: TBCB CG22 CKAP1

Protein Name: Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B)

ID gène: 1155

UniProt: Q99426