RND3 anticorps (AA 51-150)

N° du produit ABIN762356

L’anticorps Lapin Polyclonal anti-RND3 a été validé pour ELISA, IHC (p), IF (cc), IF (p) et IHC (fro). Il convient pour détecter RND3 dans des échantillons de Humain et Rat.

Aperçu rapide pour RND3 anticorps (AA 51-150) (ABIN762356)

Antigène: RND3 (rho Family GTPase 3 (RND3))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RND3 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-RND3 anticorps

Épitope: AA 51-150

Réactivité croisée: Humain, Rat

Homologie: Mouse,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human RND3

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur RND3

Antigène: RND3 (rho Family GTPase 3 (RND3))

Autre désignation: Rnd3

Sujet:

Synonyms: ARHE, memB, Rho family GTPase 3, Rho8, RhoE, RND3_HUMAN.

Background: The Rho family of proteins mediates cytoskeleton organization and cell motility responses. This family contains twenty different members divided into five groups, the Rho-like, Rac-like, Cdc42-like, Rnd and RhoBTB subfamilies. Rho proteins have GTPase activity and bind GTP in their active form and GDP in their inactive form. In their active form they interact with downstream proteins. However, the Rnd subfamily of proteins containing the Rnd1, Rnd2 and RhoE(Rnd3), binds GTP but not GDP and has no GTPase activity. While Rho proteins are required for stress fibre formation in cultured fibroblasts, epithelial and endothelial cells, overexpression of Rnd3 or Rnd1 in the same cells may cause an opposite effect (i.e. decrease in stress fibre). Thus, the Rnd3 protein may act as an antagonist for the Rho proteins either by directly binding to Rho or to other downstream proteins.

ID gène: 390