ESR2 anticorps (AA 512-530)
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- Antigène Voir toutes ESR2 Anticorps
- ESR2 (Estrogen Receptor 2 (ESR2))
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Épitope
- AA 512-530
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Reactivité
- Humain, Souris
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp ESR2 est non-conjugé
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificité
- Monoclonal antibody 4ERβ-2D7 recognizes an epitope in the F region of the mouse and human Estrogen Receptor beta. The two different forms of the estrogen receptor, usually referred to as α and β, can form hormone-activated dimers, and, since the two forms are coexpressed in many cell types, the receptors may form ERα (αα) or ERβ (ββ) homodimers or ERαβ (αβ) heterodimers. Estrogen receptor alpha and beta show significant overall sequence homology, and both are composed of five domains (A-F domains listed from the N- to C-terminus). Antigen distribution: The antigen has been described in kidney, brain, bone, heart, lungs, intestinal mucosa, prostate, and endothelial cells. No cross-reactivity has been observedwith ER-alpha
- Réactivité croisée (Details)
- Species reactivity (tested):Human and Mouse.
- Purification
- Affinity Chromatography
- Immunogène
- Peptide C512 to Q530 from murine ERbeta. Antigen: Estrogen Receptor beta. Epitope: Located in the F region.
- Clone
- ERbeta-2D7
- Isotype
- IgG1
- Top Product
- Discover our top product ESR2 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Reconstitution
- Restore by adding 0.5 mL distilled water
- Concentration
- 0.5 mg/mL
- Buffer
- Stock solution contains 0.5 mg/mL IgG, PBS, pH 7.2 with 5 mg/mL BSA as stabilizer and 0.01 % Kathon as a preservative.
- Agent conservateur
- Kathon CG
- Précaution d'utilisation
- This product contains Kathon CG a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the lyophilized antibody at 2- 8 °C. Following reconstitution, store at -20 °C.
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- Antigène
- ESR2 (Estrogen Receptor 2 (ESR2))
- Autre désignation
- Estrogen Receptor beta (ESR2 Produits)
- Synonymes
- anticorps ER-BETA, anticorps ESR-BETA, anticorps ESRB, anticorps ESTRB, anticorps Erb, anticorps NR3A2, anticorps ER[b]1, anticorps zfER-beta1, anticorps zfER[b]1, anticorps erb2, anticorps CERB, anticorps ERB, anticorps erb, anticorps esrb, anticorps estrb, anticorps nr3a2, anticorps ERbeta, anticorps er-beta, anticorps esr-beta, anticorps ESR2, anticorps ERBETA, anticorps er, anticorps ER-beta, anticorps ER[b], anticorps Estrb, anticorps ER[b]2, anticorps ER[b]a, anticorps zfER[b]2, anticorps zfER-beta2, anticorps Erb2, anticorps esr2, anticorps erbeta, anticorps Esr2, anticorps ERBeta2, anticorps estrogen receptor 2, anticorps estrogen receptor 2b, anticorps estrogen receptor beta 2, anticorps estrogen receptor 2 (beta), anticorps estrogen receptor 2a, anticorps estrogen receptor beta, anticorps ESR2, anticorps esr2b, anticorps erb2, anticorps esr2, anticorps Esr2, anticorps esr2a, anticorps erbeta
- Sujet
- ER exists in two types: alpha and Beta. They are similar in structure. The ligand binding domain and the DNA binding domain are highly conserved in these proteins while the N-terminal transactivating domain is diverged considerably. Five isoforms of the hER beta gene, designated hER beta 1-5 have been identified. ERBeta binds to estrogen and activates genes through direct interaction with estrogen specific gene elements (ERE's). ER-Beta RNA has been detected in human thymus, spleen, ovary and testis and in rat ovary and prostrate. This tissue distribution overlaps but is not identical to that of ER - alphaRNA.Synonyms: ER-beta, ESR2, ESTRB, NR3A2, Nuclear receptor subfamily 3 group A member 2
- ID gène
- 2100
- NCBI Accession
- NP_001035365
- UniProt
- Q92731
- Pathways
- Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
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