ZBTB4 anticorps (C-Term)

N° du produit ABIN783355

Cet anticorps Lapin Polyclonal détecte spécifiquement ZBTB4 dans WB et EIA. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour ZBTB4 anticorps (C-Term) (ABIN783355)

Antigène: ZBTB4 (Zinc Finger and BTB Domain Containing 4 (ZBTB4))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZBTB4 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-ZBTB4 anticorps

Épitope: C-Term

Specificité: This antibody detects ZBTB4 (C-term). At least four isoforms of ZBTB4 are known to exist, this antibody will only recognize the longest isoform. This antibody is predicted to not cross-react with other ZBTB protein family members.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid peptide near the carboxy terminus of human ZBTB4

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur ZBTB4

Antigène: ZBTB4 (Zinc Finger and BTB Domain Containing 4 (ZBTB4))

Autre désignation: ZBTB4

Sujet: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions, this degradation increases with DNA damage.Synonyms: KAISO-L1, KAISO-like zinc finger protein 1, KIAA1538, Zinc finger and BTB domain-containing protein 4

ID gène: 57659

NCBI Accession: NP_001122305

UniProt: Q9P1Z0