HMMR anticorps (N-Term)

N° du produit ABIN783397

Détail du produit anti-HMMR anticorps

Antigène: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HMMR est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects CD168 / HMMR at N-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid peptide near the amino terminus of human RHAMM

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-HMMR (ABIN783397)

Li, Ji, Wang: "Targeting Long Noncoding RNA HMMR-AS1 Suppresses and Radiosensitizes Glioblastoma." dans: Neoplasia (New York, N.Y.), Vol. 20, Issue 5, pp. 456-466, (2018) (PubMed).

Détails sur HMMR

Antigène: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Autre désignation: CD168 / HMMR (HMMR Produits)

Sujet: The hyaluronan-mediated motility receptor, also known as RHAMM, was initially identified as a soluble protein that could be released by sub-confluent migrating cells, promoting cell motility and invasion via interactions with hyaluronan (HA) and the cell surface. While RHAMM is normally poorly expressed in most normal tissues and is not required for embryonic development or normal cell homeostasis functions, its expression is increased during wound repair in response to hypoxia and fibrogenic factors. However, its overexpression is transforming in multiple types of cancers and is required for maintaining RAS transformation. RHAMM associates with BRCA1 and BARD1, attenuating the mitotic-spindle-promoting activity of RHAMM, which may contribute to tumor progression by promoting genomic instability.Synonyms: Hyaluronan mediated motility receptor, IHABP, Intracellular hyaluronic acid-binding protein, RHAMM, Receptor for hyaluronan-mediated motility

ID gène: 3161

NCBI Accession: NP_001136028

UniProt: O75330

Pathways: Glycosaminoglycan Metabolic Process