PRR5L anticorps (Center)

N° du produit ABIN783444

Détail du produit anti-PRR5L anticorps

Antigène: PRR5L (Proline Rich 5 Like (PRR5L))

Épitope: Center

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRR5L est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects PRR5L at Center. At least three isoforms of PRR5L are known to exist, this antibody will recognize only isoforms a and b. PRR5L antibody will not cross-react with PPR5.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography purified via peptide column

Immunogène: 17 amino acid peptide near the center of human PRR5L

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur PRR5L

Antigène: PRR5L (Proline Rich 5 Like (PRR5L))

Autre désignation: PRR5L (PRR5L Produits)

Synonymes: anticorps PROTOR2, anticorps 2600010E01Rik, anticorps 4833411O04Rik, anticorps Protor-2, anticorps Protor2, anticorps RGD1309969, anticorps PRR5L, anticorps FLJ14213, anticorps proline rich 5 like, anticorps PRR5L, anticorps Prr5l, anticorps prr5l

Sujet: Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2). PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2. Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.Synonyms: FLJ14213, PROTOR2, Proline-rich protein 5-like, Protein observed with Rictor-2

ID gène: 79899

NCBI Accession: NP_001153639

UniProt: Q6MZQ0