NUMB anticorps (C-Term)

N° du produit ABIN783468

Détail du produit anti-NUMB anticorps

Antigène: NUMB (Numb Homolog (NUMB))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUMB est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects NUMB at C-term. At least four isoforms of NUMB are known to exist, this antibody will detect all of them.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 17 amino acid peptide near the carboxy terminus of human NUMB

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur NUMB

Antigène: NUMB (Numb Homolog (NUMB))

Autre désignation: NUMB (NUMB Produits)

Synonymes: anticorps C14orf41, anticorps S171, anticorps c14_5527, anticorps Nb, anticorps NUMB, endocytic adaptor protein, anticorps numb homolog (Drosophila), anticorps NUMB, anticorps Numb, anticorps numb

Sujet: NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells (1,2). NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.Synonyms: Protein S171, Protein numb homolog, h-Numb

ID gène: 8650

NCBI Accession: NP_001005743

UniProt: P49757

Pathways: Cell-Cell Junction Organization