TRMT12 anticorps (N-Term)

N° du produit ABIN783482

Détail du produit anti-TRMT12 anticorps

Antigène: TRMT12 (tRNA Methyltransferase 12 Homolog (TRMT12))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRMT12 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects TRMT12 at N-term. TYW2 antibody is predicted to not cross-react with other TYW protein family members. At least two isoforms of TYW2 are known to exist, this antibody will detect both isoforms.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography purified via peptide column

Immunogène: 19 amino acid peptide near the amino terminus of human TYW2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur TRMT12

Antigène: TRMT12 (tRNA Methyltransferase 12 Homolog (TRMT12))

Autre désignation: TRMT12 (TRMT12 Produits)

Synonymes: anticorps 4632406N01Rik, anticorps AI449275, anticorps Tyw2, anticorps TRM12, anticorps TYW2, anticorps RGD1307127, anticorps trmt12, anticorps tRNA methyltranferase 12, anticorps tRNA methyltransferase 12 homolog, anticorps tRNA methyltransferase 12, anticorps tRNA methyltransferase 12 homolog (S. cerevisiae), anticorps Trmt12, anticorps TRMT12, anticorps trmt12

Sujet: TYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.Synonyms: TRM12, TYW2, tRNA methyltransferase 12, tRNA wybutosine-synthesizing protein 2 homolog, tRNA-yW-synthesizing protein 2

ID gène: 55039

NCBI Accession: NP_060426

UniProt: Q53H54