GEMC1 anticorps (Center)

N° du produit ABIN783498

Détail du produit anti-GEMC1 anticorps

Antigène: GEMC1 (GMNC) (Geminin Coiled-Coil Domain Containing (GMNC))

Épitope: Center

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GEMC1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects GEMC1 at Center.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography purified via peptide column

Immunogène: 19 amino acid peptide near the center of human GEMC1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azi

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur GEMC1

Antigène: GEMC1 (GMNC) (Geminin Coiled-Coil Domain Containing (GMNC))

Autre désignation: GEMC1 (GMNC Produits)

Synonymes: anticorps GEMC1, anticorps Gemc1, anticorps Gm1778, anticorps Gm606, anticorps gemc1, anticorps xGEMC1, anticorps geminin coiled-coil domain containing, anticorps geminin coiled-coil domain containing S homeolog, anticorps GMNC, anticorps Gmnc, anticorps gmnc.S

Sujet: The Geminin coiled-coil domain-containing protein 1 (GEMC1) is a highly conserved protein that is required for chromosomal replication. GEMC1 contains a region similar to the coiled-coil domain of geminin, an essential vertebrate replication protein in which the coiled-coil domain is required for the function. GEMC1 binds to the checkpoint and replication factor TopBP1, allowing the binding of GEMC1 to chromatin during pre-replication complex formation. GEMC1 also directly interacts with replication factors Cdc45 and Cdk2-CyclinE and stimulates the initiation of DNA replication. Depletion of GEMC1 by siRNA in embryonic and somatic vertebrate cells prevents DNA replication due to impairment of Cdc45 loading onto chromatin, suggesting GEMC1 promotes initiation of DNA replication by mediating TopBP1 and Cdk2 dependent recruitment of Cdc45 onto replication origins.Synonyms: Geminin coiled-coil domain-containing protein 1

ID gène: 647309

NCBI Accession: NP_001140158

UniProt: A6NCL1