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FRMPD2 anticorps (N-Term)

FRMPD2 Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN783582
  • Antigène Voir toutes FRMPD2 Anticorps
    FRMPD2 (FERM and PDZ Domain Containing 2 (FRMPD2))
    Épitope
    • 2
    • 2
    • 1
    • 1
    N-Term
    Reactivité
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 3
    • 2
    Lapin
    Clonalité
    • 5
    Polyclonal
    Conjugué
    • 5
    Cet anticorp FRMPD2 est non-conjugé
    Application
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    15 amino acid peptide from near the amino terminus of human FRMPD2
    Top Product
    Discover our top product FRMPD2 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody (in aliquots) at -20 °C.
  • Antigène
    FRMPD2 (FERM and PDZ Domain Containing 2 (FRMPD2))
    Autre désignation
    FRMPD2 (FRMPD2 Produits)
    Synonymes
    anticorps Frmpd2, anticorps Gm1582, anticorps ENSMUSG00000071536, anticorps FRMPD2, anticorps PDZD5C, anticorps PDZK4, anticorps PDZK5C, anticorps FERM and PDZ domain containing 2, anticorps putative protein FRMPD2-like, anticorps FERM and PDZ domain-containing protein 2, anticorps Frmpd2, anticorps FRMPD2, anticorps LOC100051923, anticorps LOC100348282, anticorps LOC100548446
    Sujet
    The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL (4). FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.Synonyms: FERM and PDZ domain-containing protein 2, PDZ domain-containing protein 4, PDZ domain-containing protein 5C, PDZD5C, PDZK4, PDZK5C
    ID gène
    143162
    NCBI Accession
    NP_001018081
    UniProt
    Q68DX3
    Pathways
    Cell-Cell Junction Organization
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