NLRC3 anticorps (Center)

N° du produit ABIN783697

Cet anticorps Lapin Polyclonal détecte spécifiquement NLRC3 dans WB et EIA. Il présente une réactivité avec des échantillons de Souris, Humain et Rat.

Aperçu rapide pour NLRC3 anticorps (Center) (ABIN783697)

Antigène: NLRC3 (NLR Family, CARD Domain Containing 3 (NLRC3))

Reactivité: Souris, Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRC3 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-NLRC3 anticorps

Épitope: Center

Specificité: This antibody detects NOD3 at Center.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid peptide near the center of human NOD3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur NLRC3

Antigène: NLRC3 (NLR Family, CARD Domain Containing 3 (NLRC3))

Autre désignation: NOD3

Sujet: NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-?B, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.Synonyms: CLR16.2, FLJ00348, NLRC3, NOD3

ID gène: 197358

NCBI Accession: NP_849172

UniProt: Q7RTR2