ZFYVE26 anticorps (C-Term)

N° du produit ABIN783824

Détail du produit anti-ZFYVE26 anticorps

Antigène: ZFYVE26 (Zinc Finger, FYVE Domain Containing 26 (ZFYVE26))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZFYVE26 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to ZFYVE26.

Purification: Affinity chromatography

Immunogène: 16 amino acid peptide near the carboxy terminus of human SPG15.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: PBS containing 0.02 % sodium azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur ZFYVE26

Antigène: ZFYVE26 (Zinc Finger, FYVE Domain Containing 26 (ZFYVE26))

Autre désignation: ZFYVE26 (ZFYVE26 Produits)

Synonymes: anticorps wu:fc33a03, anticorps FYVE-CENT, anticorps SPG15, anticorps 4930465A13, anticorps 9330197E15Rik, anticorps A630028O16Rik, anticorps Gm893, anticorps mKIAA0321, anticorps zinc finger, FYVE domain containing 26, anticorps zinc finger FYVE-type containing 26, anticorps zfyve26, anticorps ZFYVE26, anticorps Zfyve26

Sujet: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders. Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. SPG15 encodes a protein containing a FYVE zinc finger binding domain which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. SPG15 mRNA is widely distributed in human tissues, as well as in rat embryos, suggesting a possible role for this protein during embryonic development. SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, suggesting a role in intracellular trafficking. Multiple isoforms of SPG15 are known to exist.Synonyms: KIAA0321, Zinc finger FYVE domain-containing protein 26

ID gène: 23503

NCBI Accession: NP_056161

UniProt: Q68DK2