RWDD3 anticorps (N-Term)

N° du produit ABIN783831

Détail du produit anti-RWDD3 anticorps

Antigène: RWDD3 (RWD Domain Containing 3 (RWDD3))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RWDD3 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to RWD domain containing 3.

Purification: Affinity chromatography

Immunogène: 17 amino acid peptide from near the amino terminus of human RWDD3.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur RWDD3

Antigène: RWDD3 (RWD Domain Containing 3 (RWDD3))

Autre désignation: RWDD3 (RWDD3 Produits)

Synonymes: anticorps DKFZp469N1913, anticorps RSUME, anticorps 2510027J23Rik, anticorps 3110037C01Rik, anticorps AI035684, anticorps AI662458, anticorps X2CR1, anticorps X2cr1, anticorps zgc:73229, anticorps RWD domain containing 3, anticorps RWDD3, anticorps rwdd3, anticorps Rwdd3

Sujet: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune inflammatory signals. RWDD3 increases Ikbeta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha-induced kB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikbeta increased stability. RSUME-enhanced sumoylation of Ikbeta leads to the inhibition of NF-kbeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.Synonyms: RSUME, RWD domain-containing protein 3, RWD-containing sumoylation enhancer

ID gène: 25950

NCBI Accession: NP_001121614

UniProt: Q9Y3V2