ZEB2 anticorps (C-Term)

N° du produit ABIN784073

L’anticorps Lapin Polyclonal anti-ZEB2 a été validé pour WB, IF, IHC (p) et EIA. Il convient pour détecter ZEB2 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ZEB2 anticorps (C-Term) (ABIN784073)

Antigène: ZEB2 (Zinc Finger E-Box Binding Homeobox 2 (ZEB2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZEB2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-ZEB2 anticorps

Épitope: C-Term

Specificité: This antibody reacts to the C-term of ZEB2.

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogène: ZEB2 antibody was raised against an 18 amino acid synthetic near the carboxy terminus of Human ZEB2.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ZEB2

Antigène: ZEB2 (Zinc Finger E-Box Binding Homeobox 2 (ZEB2))

Autre désignation: ZFHX1B

Sujet: ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.Synonyms: KIAA0569, SIP1, SMADIP1, Smad-interacting protein 1, ZEB2, ZFX1B, Zinc finger E-box-binding homeobox 2, Zinc finger homeobox protein 1b

ID gène: 9839

NCBI Accession: NP_001165124

Pathways: Tube Formation