DPYSL2 anticorps (C-Term)

N° du produit ABIN784201

Détail du produit anti-DPYSL2 anticorps

Antigène: DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DPYSL2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects endogenous levels of total DPYSL2 protein.

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography.

Immunogène: Synthetic peptide - KLH conjugated Remarks: Antigen Modification: C-Terminus

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM Sodium Chloride, 0.02 % Sodium Azide and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur DPYSL2

Antigène: DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))

Autre désignation: DPYSL2 / CRMP2 (DPYSL2 Produits)

Synonymes: anticorps CRMP-2, anticorps CRMP2, anticorps DHPRP2, anticorps DRP-2, anticorps DRP2, anticorps N2A3, anticorps ULIP-2, anticorps ULIP2, anticorps TOAD-64, anticorps crmp2, anticorps dhprp2, anticorps drp-2, anticorps drp2, anticorps unc-33, anticorps unc33, anticorps dpysl2, anticorps CRMP 2, anticorps PCRMP 2, anticorps PCRMP-2, anticorps PCRMP2, anticorps PfCRMP 2, anticorps PfCRMP-2, anticorps AI851130, anticorps Crmp2, anticorps Musunc33, anticorps Ulip2, anticorps CRMP2A, anticorps dihydropyrimidinase like 2, anticorps dihydropyrimidinase-like 2, anticorps dihydropyrimidinase like 2 L homeolog, anticorps dihydropyrimidinase-like 2b, anticorps cysteine repeat modular protein 2, putative, anticorps DPYSL2, anticorps dpysl2.L, anticorps dpysl2b, anticorps PfCRMP2, anticorps dpysl2, anticorps Dpysl2

Sujet: DRP-2, also known as Collapsin Response Mediator Protein-2 (CRMP-2), is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity. CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly. GSK-3b inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3b. Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway. CRMP-2 also mediates semaphorin-induced growth cone collapse. Hyperphosphorylation of CRMP-2 and is found in Alzheimer disease plaques with concurrent elevated GSK-3b activity in these patients.Synonyms: Collapsin response mediator protein 2, DRP-2, Dihydropyrimidinase-related protein 2, N2A3

ID gène: 1808

NCBI Accession: NP_001184222

Pathways: Regulation of Cell Size