GRM7 anticorps (pSer862)

N° du produit ABIN784604

L’anticorps Lapin Polyclonal anti-GRM7 a été validé pour IHC (fro). Il convient pour détecter GRM7 dans des échantillons de Humain, Rat, Souris, Chien, Boeuf (Vache), Poisson zèbre (Danio rerio) et Non-Human Primate.

Aperçu rapide pour GRM7 anticorps (pSer862) (ABIN784604)

Antigène: GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))

Reactivité: Humain, Rat, Souris, Chien, Boeuf (Vache), Poisson zèbre (Danio rerio), Non-Human Primate

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRM7 est non-conjugé

Application: Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-GRM7 anticorps

Épitope: pSer862

Specificité: Specific for the ~102k mGluR7 protein phosphorylated at Ser862. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide used as antigen but not by the corresponding dephosphopeptide.

Réactivité croisée (Details): Species reactivity (expected):Bovine, Canine, Human, non-Human Primate and Zebrafish.
Species reactivity (tested):Mouse and Rat.

Purification: Affinity Chromatography.

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding phospho-Ser862 of Rat mGluR7.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Détails sur GRM7

Antigène: GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))

Autre désignation: mGluR7 / GRM7

Sujet: Metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004, Francesconi et al., 2004, Wilson and Nicoll, 2001). The mGluRs are divided into three groups based on sequence identity and pharmacological properties: group I (mGluR1 and mGluR5) are localized in the perisynaptic region of the postsynaptic membrane, whereas group II (mGlur2 and mGluR3) and group III (mGluR4,6,7 and 8) are localized predominantly at presynaptic terminals. PKC phosphorylation of serine 862 on mGluR7 has been shown to be critical for stabilizing receptor surface expression and promoting binding to the synaptic PDZ-domain-containing protein PICK1 (Suh et al., 2008).Synonyms: GPRC1G, MGLUR7, Metabotropic glutamate receptor 7

ID gène: 81672

NCBI Accession: NP_112302

Pathways: Sensory Perception of Sound, cAMP Metabolic Process, Feeding Behaviour