GAP43 anticorps (AA 216-226)

N° du produit ABIN789021

Cet anticorps anti-GAP43 est un anticorps Lapin Polyclonal détectant GAP43 dans WB, IHC et FACS. Adapté pour Humain, Rat, Souris et Poulet.

Aperçu rapide pour GAP43 anticorps (AA 216-226) (ABIN789021)

Antigène: GAP43 (Growth Associated Protein 43 (GAP43))

Reactivité: Humain, Rat, Souris, Poulet

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GAP43 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Détail du produit anti-GAP43 anticorps

Épitope: AA 216-226

Réactivité croisée: Poulet, Humain, Souris, Rat (Rattus)

Purification: affinity purified

Immunogène: Synthetic peptide corresponding to AA 216-226 of rat/mouse GAP-43, (C)-KEDPEADQEHA coupled to maleimide-activated KLH.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: -20 °C

Détails sur GAP43

Antigène: GAP43 (Growth Associated Protein 43 (GAP43))

Autre désignation: GAP43

Sujet: GAP-43 (growth associated protein 43 kDa, also known as neuromodulin) is a 24 kDa, neuron growth cone-associated member of the neuromodulin family. Apparently due to its tertiary structure, it runs anomalously at 43 kDa on SDS-polyacrylamide gel. Rat GAP-43 is a 226 amino acid (aa) protein that contains an N-terminal lipid binding motif, an 11 aa IQ domain (IQ:Ile-Gln-X-Ser-etc) (aa 38 - 48), and a C-terminus with four potential serine phosphorylation sites. The molecule may utilize the IQ domain to bind calmodulin. Protein kinase C-mediated phosphorylation of the Serine at 41 within this site inhibits this interaction. Unphosphorylated, calmodulin-bound GAP-43 is always associated with neurite retraction, while S41 phosphorylated GAP-43 stabilizes actin filaments and promotes growth cone extension.