GIT1 anticorps (pTyr545) (FITC)
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- Antigène Voir toutes GIT1 Anticorps
- GIT1
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Épitope
- pTyr545
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp GIT1 est conjugé à/à la FITC
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Cow,Pig
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic phosphopeptide derived from human GIT1 around the phosphorylation site of Tyr545
- Isotype
- IgG
- Top Product
- Discover our top product GIT1 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- GIT1
- Autre désignation
- GIT1 (GIT1 Produits)
- Synonymes
- anticorps Cat-1, anticorps p95Cat, anticorps GIT ArfGAP 1, anticorps G protein-coupled receptor kinase interacting ArfGAP 1, anticorps G protein-coupled receptor kinase-interactor 1, anticorps GIT1, anticorps Git1
- Sujet
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Synonyms: GIT1 phospho Tyr545, p-GIT1 Tyr545, ARF GAP GIT1, ARF GTPase activating protein GIT1, CAT 1, Cat1, Cool associated and tyrosine phosphorylated protein 1, G protein coupled receptor kinase interactor 1, GRK interacting protein 1.
Background: Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).
- ID gène
- 28964
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