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HSPA4 anticorps

HSPA4 Reactivité: Hamster WB, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN863194
  • Antigène Voir toutes HSPA4 Anticorps
    HSPA4 (Heat Shock 70kDa Protein 4 (HSPA4))
    Reactivité
    • 52
    • 34
    • 30
    • 11
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Hamster
    Hôte
    • 55
    • 8
    Lapin
    Clonalité
    • 47
    • 16
    Polyclonal
    Conjugué
    • 28
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HSPA4 est non-conjugé
    Application
    • 50
    • 17
    • 17
    • 13
    • 12
    • 11
    • 8
    • 5
    • 4
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    Detects ~110 kDa.
     Réactivité croisée
    Boeuf (Vache), Hamster, Humain, Singe, Souris, Rat, Saccharomyces cerevisiae, Requin, Mouton
    Purification
    Protein A Purified
    Immunogène
    Synthetic peptide derived from the sequence of hamster HSP110, sequence identical to human and mouse
  • Indications d'application
    • WB (1:1000)
    • IHC (1:100)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    1 μg/ml of ABIN863193 was sufficient for detection of HSP110 in 10 μg of human cell line mixed lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.2, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C
  • Eng, Reed, Kokolus, Repasky: "Housing temperature influences the pattern of heat shock protein induction in mice following mild whole body hyperthermia." dans: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, Vol. 30, Issue 8, pp. 540-6, (2014) (PubMed).

  • Antigène
    HSPA4 (Heat Shock 70kDa Protein 4 (HSPA4))
    Autre désignation
    HSP110 (HSPA4 Produits)
    Synonymes
    anticorps APG-2, anticorps HS24/P52, anticorps HSPH2, anticorps RY, anticorps hsp70, anticorps hsp70RY, anticorps Hsp110, anticorps Hsp70, anticorps irp94, anticorps 70kDa, anticorps AI317151, anticorps Hsp70RY, anticorps mKIAA4025, anticorps hspa4, anticorps wu:fi30e11, anticorps zgc:55743, anticorps zgc:77413, anticorps hs24/p52, anticorps hspa4-a, anticorps osp94, anticorps pg-2, anticorps hspa4l, anticorps wu:fc41d05, anticorps wu:fi59h02, anticorps wu:fj35c08, anticorps zgc:55506, anticorps heat shock protein family A (Hsp70) member 4, anticorps heat shock protein family A member 4, anticorps heat shock protein 4, anticorps heat shock protein 4b, anticorps heat shock protein family A (Hsp70) member 4 S homeolog, anticorps heat shock protein 4a, anticorps HSPA4, anticorps Hspa4, anticorps hspa4b, anticorps hspa4.S, anticorps hspa4a
    Sujet
    HSP110 belongs to a family of large stress proteins known as the HSP110/SSE Family. The proteins in this family are the most distantly known relatives of the well studied HSP70 family. They share 30-33 % amino acid identity, mostly in the conserved ATP-binding domain (1). HSP110 cooperates with HSP70 in protein folding in the eukaryotic cytosol (2). In mammals, HSP110 is constitutively expressed, but exhibits particularly high levels in the brain. Both HSP70 and HSP110 are elevated after cerebral ischemia. Recent studies demonstrate that the protective effects of HSP110 deficiency in cerebral ischemia may partly be mediated by an increase in the chaperone activity of HSP70 (3). Studies also suggest that HSP110 can be used in heat shock protein-based cancer immunotherapy (4).
    ID gène
    10808
    NCBI Accession
    NP_006635
    UniProt
    Q92599
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