Bassoon anticorps (AA 786-1041)

N° du produit ABIN863198

Détail du produit anti-Bassoon anticorps

Antigène: Bassoon (BSN)

Épitope: AA 786-1041

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Bassoon est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Specificité: Detects ~420 kDa. Multiple isoforms can be detected.

Réactivité croisée: Humain, Souris, Rat

Purification: Protein A Purified

Immunogène: NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein

Information d'application

Indications d'application:

• WB (1:1000)
• IHC (1:400)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1 μg/ml of ABIN863198 was sufficient for detection of Bassoon in 10 μg of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C

Détails sur Bassoon

Antigène: Bassoon (BSN)

Autre désignation: Bassoon (BSN Produits)

Synonymes: anticorps Znf231, anticorps ZNF231, anticorps bassoon, anticorps bassoon (presynaptic cytomatrix protein), anticorps bassoon presynaptic cytomatrix protein, anticorps Bsn, anticorps BSN

Sujet: Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntington, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to co-localize with GABA (A) and glutamate (GluR1) receptors (1).

ID gène: 8927

NCBI Accession: NP_003449

UniProt: Q9UPA5