Amyloid anticorps
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- Antigène
- Amyloid
- Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Inconjugué
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Application
- ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificité
- Recognizes all types of amyloid oligomers. Appears to recog a peptide backbone epitope common to amyloid oligomers, but not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.
- Réactivité croisée
- Eucaryotes, Humain, Souris, Rat
- Purification
- Protein A Purified
- Immunogène
- Synthetic molecular mimic of soluble oligomers
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- Indications d'application
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- WB (1:200)
- IP (1:200)
- optimal dilutions for assays should be determined by the user.
- Commentaires
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A 1:200 dilution of ABIN863210 was sufficient for detection of amyloid oligomers in 10 μg of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- -20°C
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Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 34, Issue 7, pp. 9156-9179, (2020) (PubMed).
: "Acute amnestic encephalopathy in amyloid-β oligomer-injected mice is due to their widespread diffusion in vivo." dans: Neurobiology of aging, Vol. 36, Issue 6, pp. 2043-52, (2015) (PubMed).
: "
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Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 34, Issue 7, pp. 9156-9179, (2020) (PubMed).
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- Antigène
- Amyloid
- Synonymes
- anticorps amyloid beta precursor protein, anticorps App
- Sujet
- Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).
- ID gène
- 8666
- NCBI Accession
- NM_000484
- UniProt
- P05067
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