SNAIL anticorps

N° du produit ABIN865486

Cet anticorps Souris Monoclonal détecte spécifiquement SNAIL dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour SNAIL anticorps (ABIN865486)

Antigène: SNAIL (SNAI1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SNAIL est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 6D2

Détail du produit anti-SNAIL anticorps

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human SNAI1 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100g/100l

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Détails sur SNAIL

Antigène: SNAIL (SNAI1)

Autre désignation: SNAI1

Sujet: Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function . Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney. Synonyms: SNA, SNAH, SLUGH2, dJ710H13.1, SNAI1

Poids moléculaire: 29kDa

ID gène: 6615

Pathways: Negative Regulation of intrinsic apoptotic Signaling