BAT3 anticorps (AA 1042-1132)

N° du produit ABIN872366

Détail du produit anti-BAT3 anticorps

Antigène: BAT3 (Large Proline-Rich Protein BAT3 (BAT3))

Épitope: AA 1042-1132

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAT3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human BAT3/BAG6

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur BAT3

Antigène: BAT3 (Large Proline-Rich Protein BAT3 (BAT3))

Autre désignation: BAG6 (BAT3 Produits)

Synonymes: anticorps ARABIDOPSIS THALIANA BCL-2-ASSOCIATED ATHANOGENE 6, anticorps ATBAG6, anticorps BCL-2-associated athanogene 6, anticorps T3F17.11, anticorps 2410045D21Rik, anticorps AA408914, anticorps BAG-6, anticorps Bat3, anticorps D17H6S52E, anticorps G3, anticorps Scythe, anticorps BAT3, anticorps D6S52E, anticorps BCL-2-associated athanogene 6, anticorps BCL2-associated athanogene 6, anticorps BCL2 associated athanogene 6, anticorps BAG6, anticorps Bag6

Sujet:

Synonyms: family molecular chaperone regulator 6, BAG-6, BAG6, Bag6, BAG6_HUMAN, BCL2-associated athanogene 6, D6S52E, G3, HLA B associated transcript 3, HLA-B-associated transcript 3, Large proline-rich protein BAG6, Protein G3, Protein Scythe.

Background: Chaperone that plays a key role in various processes such as apoptosis, insertion of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane and regulation of chromatin. Acts in part by regulating stability of proteins and their degradation by the proteasome. Participates in endoplasmic reticulum stress-induced apoptosis via its interaction with AIFM1/AIF by regulating AIFM1/AIF stability and preventing its degradation. Also required during spermatogenesis for synaptonemal complex assembly via its interaction with HSPA2, by inhibiting polyubiquitination and subsequent proteasomal degradation of HSPA2. Required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, may play a role in immuno-proteasomes to generate antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response. Key component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. BAG6/BAT3 acts by facilitating TA membrane proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins and transfers them to ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane.