SUPT16H anticorps (AA 601-700)

N° du produit ABIN873073

Cet anticorps Lapin Polyclonal détecte spécifiquement SUPT16H dans ELISA, WB, IHC (p), IF (cc), IF (p) et IHC (fro). Il présente une réactivité envers Souris.

Aperçu rapide pour SUPT16H anticorps (AA 601-700) (ABIN873073)

Antigène: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUPT16H est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-SUPT16H anticorps

Épitope: AA 601-700

Réactivité croisée: Souris

Homologie: Human,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SUPT16H/CDC68

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur SUPT16H

Antigène: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Autre désignation: SUPT16H

Sujet:

Synonyms: CDC68, Chromatin specic transcription elongation factor 140 kDa subunit, Chromatin-specic transcription elongation factor 140 kDa subunit, Facilitates chromatin transcription complex subunit SPT16, FACT 140 kDa subunit, FACT, FACT complex subunit SPT16, FACTP140, FLJ10857, FLJ14010, hSPT16, SP16H_HUMAN, Suppressor of Ty 16 homolog, Supt16h.

Background: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

ID gène: 11198

Pathways: Chromatin Binding