Complement C3c anticorps (AA 1051-1200)

N° du produit ABIN873279

Cité dans 1 publication. Cet anticorps anti-Complement C3c Polyclonal Lapin (ABIN873279) détecte spécifiquement Complement C3c dans WB, IF (p), IF (cc), IHC (fro) et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Complement C3c anticorps (AA 1051-1200) (ABIN873279)

Antigène: Complement C3c (C3C) (Complement Component C3c (C3C))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Complement C3c est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Complement C3c anticorps

Épitope: AA 1051-1200

Fonction: Complement C3 Antibody

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Complement C3dg fragment 1

Isotype: IgG

Information d'application

Indications d'application: WB(1:300-5000),

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Complement C3c (ABIN873279)

Vass, Süveges, Érces, Nógrády, Varga, Földesi, Futakuchi, Imai, Okada, Okada, Boros, Kaszaki: "Inflammatory activation after experimental cardiac tamponade." dans: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes, Vol. 51, Issue 1-2, pp. 1-13, (2013) (PubMed).

Détails sur Complement C3c

Antigène: Complement C3c (C3C) (Complement Component C3c (C3C))

Autre désignation: Complement Fragment 3c

Sujet:

Synonyms: ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p, Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3

Background: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:837664, PubMed:29953, PubMed:959512, PubMed:1432298, PubMed:15833747, PubMed:16333141, PubMed:1961575).

ID gène: 718

UniProt: P01024