ERAP1 anticorps (AA 651-730)

N° du produit ABIN873313

Cet anticorps Lapin Polyclonal détecte spécifiquement ERAP1 dans ELISA, IHC (p), IF (cc), IF (p) et IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour ERAP1 anticorps (AA 651-730) (ABIN873313)

Antigène: ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERAP1 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-ERAP1 anticorps

Épitope: AA 651-730

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ARTS1

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur ERAP1

Antigène: ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))

Autre désignation: ARTS1

Sujet:

Synonyms: Endoplasmic reticulum aminopeptidase 1, A LAP, A-LAP, Adipocyte derived leucine aminopeptidase, Adipocyte-derived leucine aminopeptidase, ALAP, Aminopeptidase PILS, APPILS, ARTS 1, ARTS-1, Arts1, Endoplasmic reticulum aminopeptidase 1, ERAAP, ERAP 1, Erap1, ERAP1_HUMAN, PILS AP, PILS-AP, PILSA, PILSAP, Puromycin insensitive leucyl specic aminopeptidase, Puromycin-insensitive leucyl-specic aminopeptidase, Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, VEGF-induced aminopeptidase.

Background: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

ID gène: 51752