ASB3 anticorps (AA 21-120) (Biotin)

N° du produit ABIN883755

Cet anticorps anti-ASB3 est un anticorps Lapin Polyclonal détectant ASB3 dans ELISA, IHC (fro) et IHC (p). Adapté pour Humain et Souris.

Aperçu rapide pour ASB3 anticorps (AA 21-120) (Biotin) (ABIN883755)

Antigène: ASB3 (Ankyrin Repeat and SOCS Box-Containing 3 (ASB3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASB3 est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ASB3 anticorps (Biotin)

Épitope: AA 21-120

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Cow,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ASB3

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur ASB3

Antigène: ASB3 (Ankyrin Repeat and SOCS Box-Containing 3 (ASB3))

Autre désignation: ASB3

Sujet:

Synonyms: Ankyrin repeat and SOCS box containing 3, Ankyrin repeat and SOCS box containing protein 3, Ankyrin repeat and SOCS box protein 3, ASB-3, ASB3, ASB3_HUMAN, Weakly similar to ankyrin brain variant 2.

Background: Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the elongin B and C complex. Serveral other families of proteins also contain SOCS boxes but differ from the SOCS proteins in the type of domain they contained upstream of the SOCS box. Four members of the ankyrin repeat and SOCS box-containing (ASB) protein family are identified and termed as ASB-1, ASB-2, ASB-3 and ASB-4. ASB-1 is expressed in multiple organs, including the hematopoietic compartment. ASB-1 knock-out mice display a diminution of spermatogenesis with less complete filling of seminiferous tubules. Asb-2 is a novel retinoic-acid (RA)-induced gene in acute promyelocytic leukemia (APL) cells and its expression induces growth-inhibition and chromatin condensation recapitulating early events critical to RA-induced differentiaiton of APL cells. ASB-2 is directly induced by all-trans retinotic acid, by the binding of RARa to the RAR binding element/RXR binding element in the Asb-2 promoter.

ID gène: 51130