Uromodulin anticorps (AA 351-450) (AbBy Fluor® 488)

N° du produit ABIN905878

Cet anticorps Lapin Polyclonal détecte spécifiquement Uromodulin dans WB, FACS, IF (cc) et IF (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour Uromodulin anticorps (AA 351-450) (AbBy Fluor® 488) (ABIN905878)

Antigène: Uromodulin (UMOD)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Uromodulin est conjugé à/à la AbBy Fluor® 488

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-Uromodulin anticorps (AbBy Fluor® 488)

Épitope: AA 351-450

Réactivité croisée: Humain, Souris, Rat

Homologie: Cow

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from Human Uromodulin

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Uromodulin

Antigène: Uromodulin (UMOD)

Autre désignation: Uromodulin

Sujet:

Synonyms: ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, medullary cystic kidney disease 2 autosomal dominant, Tamm Horsfall glycoprotein, Tamm Horsfall urinary glycoprotein, Tamm-Horsfall urinary glycoprotein, THGP, THP, Umod, UROM_HUMAN, Uromodulin.

Background: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. Uromodulin, secreted form: Secreted into urine after proteolytical cleavage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals.

ID gène: 7369

UniProt: P07911