NEUROD1 anticorps (AA 21-120) (AbBy Fluor® 647)

N° du produit ABIN908093

L’anticorps Lapin Polyclonal anti-NEUROD1 a été validé pour WB, FACS, IF (cc) et IF (p). Il convient pour détecter NEUROD1 dans des échantillons de Souris et Rat.

Aperçu rapide pour NEUROD1 anticorps (AA 21-120) (AbBy Fluor® 647) (ABIN908093)

Antigène: NEUROD1 (Neuronal Differentiation 1 (NEUROD1))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEUROD1 est conjugé à/à la AbBy Fluor® 647

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-NEUROD1 anticorps (AbBy Fluor® 647)

Épitope: AA 21-120

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human NeuroD1

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur NEUROD1

Antigène: NEUROD1 (Neuronal Differentiation 1 (NEUROD1))

Autre désignation: Neurod1

Sujet:

Synonyms: BETA2, BHF-1, MODY6, NEUROD, bHLHa3, Neurogenic differentiation factor 1, NeuroD1, Class A basic helix-loop-helix protein 3

Background: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).

ID gène: 4760

UniProt: Q13562

Pathways: Dopaminergic Neurogenesis, Hormone Transport, Carbohydrate Homeostasis