Nef anticorps (FITC)

N° du produit ABIN933664

Cet anticorps Souris Monoclonal détecte spécifiquement dans WB et ELISA. Il présente une réactivité envers Human Immunodeficiency Virus (HIV).

Aperçu rapide pour Nef anticorps (FITC) (ABIN933664)

Antigène: Nef

Reactivité: Human Immunodeficiency Virus (HIV)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: FITC

Application: Western Blotting (WB), ELISA

Clone: 2H12 N-terminus

Détail du produit

Réactivité croisée (Details): Reacts with recombinant nef in ELISA and WB.

Pureté: > 95 % pure

Immunogène: HIV1 Nef antibody (FITC) was raised using purified recombinant nef (HIV-1) produced in E.coli expression system as the immunogen.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:1,000, WB: 1:1,000
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Supplied lyophilized in PBS buffer.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.
Product is photosensitive and should be protected from light.
Dilute only prior to immediate use.

Stock: -80 °C

Stockage commentaire: Aliquot and store at -70 °C or lower.

Détail du antigène

Antigène: Nef

Classe de substances: Viral Protein

Sujet: Nef is a early protein that may play a role in optimizing the host cell environment for viral replication without causing apoptosis. Nef enhances virus infectivity and pathogenicity. It down regulates surface MHC I molecules and internalized molecules are sequestered to the trans-Golgi network. The number of cell surface CD4 antigen are decreased by interacting with the Src family kinase LCK thereby inducing LCK CD4 dissociation and by increasing clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation.  . Synonyms: Monoclonal HIV1 Nef antibody, Anti-HIV1 Nef antibody, HIV-1 Nef antibody, 3'ORF antibody, ABIN antibody, ABIN1 antibody,C terminal core protein antibody, F protein antibody, Nef antibody, Negative factor antibody, p27 antibody, VAN antibody.