CD2 anticorps

N° du produit ABIN94021

Cet anticorps Souris Monoclonal détecte spécifiquement CD2 dans FACS et IP. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour CD2 anticorps (ABIN94021)

Antigène: CD2

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD2 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Clone: MEM-65

Détail du produit anti-CD2 anticorps

Fonction: Anti-Hu CD2 Purified

Specificité: The antibody MEM-65 recognizes a unique extracellular epitope of CD2, a 50 kDa glycoprotein present on the human peripheral blood T-lymphocytes and NK cells, also expressed by all thymocytes.

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Human peripheral T cells.

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-CD2 (ABIN94021)

Espagnolle, Depoil, Zaru, Demeur, Champagne, Guiraud, Valitutti: "CD2 and TCR synergize for the activation of phospholipase Cgamma1/calcium pathway at the immunological synapse." dans: International immunology, Vol. 19, Issue 3, pp. 239-48, (2007) (PubMed).

Drbal, Hilgert, Cebecauer, Angelisová, Horejsí: "New monoclonal antibodies to human leucocyte surface molecule CD2." dans: Folia biologica, Vol. 43, Issue 6, pp. 245-6, (1998) (PubMed).

Détails sur CD2

Antigène: CD2

Autre désignation: CD2

Sujet: CD2 Molecule,CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.,T11, LFA-2, SRBC

ID gène: 914

UniProt: P06729