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CD38 anticorps (FITC)

Reactivité: Humain FACS Hôte: Souris Monoclonal HIT2 FITC
N° du produit ABIN94085
  • Antigène Voir toutes CD38 Anticorps
    CD38
    Reactivité
    • 157
    • 60
    • 28
    • 12
    • 12
    • 12
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 106
    • 81
    • 29
    • 1
    Souris
    Clonalité
    • 147
    • 66
    • 2
    Monoclonal
    Conjugué
    • 68
    • 16
    • 15
    • 12
    • 9
    • 7
    • 7
    • 6
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    • 5
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    • 3
    • 3
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    • 3
    • 3
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    Cet anticorp CD38 est conjugé à/à la FITC
    Application
    • 165
    • 70
    • 37
    • 35
    • 32
    • 26
    • 26
    • 22
    • 19
    • 18
    • 7
    • 7
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    • 2
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    Flow Cytometry (FACS)
    Specificité
    The mouse monoclonal antibody HIT2 reacts with an extracellular epitope of CD38, a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes, it is an antigenic marker of lymphoid cells. Its binding is blocked by daratumumab.
    Réactivité croisée (Details)
    Human
    Purification
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    Human thymocytes in foetus
    Clone
    HIT2
    Isotype
    IgG1
    Top Product
    Discover our top product CD38 Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Všianská, Říhová, Varmužová, Suská, Kryukov, Mikulášová, Kupská, Penka, Pour, Adam, Hájek: "Analysis of B-cell subpopulations in monoclonal gammopathies." dans: Clinical lymphoma, myeloma & leukemia, Vol. 15, Issue 4, pp. e61-71, (2015) (PubMed).

    Rozková, Novotná, Pytlík, Hochová, Kozák, Bart?nková, Spísek: "Toll-like receptors on B-CLL cells: expression and functional consequences of their stimulation." dans: International journal of cancer. Journal international du cancer, Vol. 126, Issue 5, pp. 1132-43, (2010) (PubMed).

    Kolar, Mehta, Pelayo, Capra: "A novel human B cell subpopulation representing the initial germinal center population to express AID." dans: Blood, Vol. 109, Issue 6, pp. 2545-52, (2007) (PubMed).

  • Antigène
    CD38
    Abstract
    CD38 Produits
    Synonymes
    anticorps T10, anticorps Cd38-rs1, anticorps cd38, anticorps ADPRC 1, anticorps cADPr hydrolase 1, anticorps CD38 molecule, anticorps CD38 antigen, anticorps CD38 molecule L homeolog, anticorps ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, anticorps CD38, anticorps Cd38, anticorps cd38.L
    Sujet
    CD38 Molecule,CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration.,ADPRC1, cADPr hydrolase 1, T10, NAD(+) nucleosidase, ADP-ribosyl cyclase 1
    ID gène
    952
    UniProt
    P28907
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