Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

CD41, CD61 anticorps

Reactivité: Humain, Boeuf (Vache) FACS, IP, ELISA, ICC Hôte: Souris Monoclonal IVA30 unconjugated
N° du produit ABIN94110
  • Antigène Voir toutes CD41, CD61 Anticorps
    CD41, CD61 (CD41,CD61)
    Reactivité
    • 18
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Boeuf (Vache)
    Hôte
    • 26
    Souris
    Clonalité
    • 26
    Monoclonal
    Conjugué
    • 10
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD41, CD61 est non-conjugé
    Application
    • 22
    • 7
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), ELISA, Immunocytochemistry (ICC)
    Specificité
    The antibody IVA30 reacts with an extracellular epitope on CD41/CD61 complex (bovine), one of the earliest markers of the megakaryocytic lineage. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, vitronectin, thrombin and mediates platelets aggregation. CD41/CD61 is expressed only by platelets and megakaryocytes, the complex may be absent or strongly reduced in Glanzmann's thrombasthenia (GT). This antibody crossreacts with human platelets.
    Réactivité croisée (Details)
    Human, Bovine
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    Bovine trombocytes.
    Clone
    IVA30
    Isotype
    IgG2
  • Indications d'application
    Flow cytometry: Recommended dilution: 1-4 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • "Proceedings of the 3rd workshop on ruminant leukocyte antigens. Davis, California, 16 July 1995." dans: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 213-468, (1997) (PubMed).

    Mateo, Perez de la Lastra, Moreno, Dusinsky, Bilka, Simon, Horovska, Llanes: "Biochemical characterization of antigens detected with anti-platelet monoclonal antibodies." dans: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 363-70, (1997) (PubMed).

    Mateo, Pintado, Perez de la Lastra, Dusinsky, Simon, Naessens, Llanes: "Ruminant cluster CD41/CD61." dans: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 251-3, (1997) (PubMed).

    Naessens, Howard, Hopkins: "Nomenclature and characterization of leukocyte differentiation antigens in ruminants." dans: Immunology today, Vol. 18, Issue 8, pp. 365-8, (1997) (PubMed).

    Simon, Dusinsky, Horovska, Bilka, Hluchy: "Immunohistochemical reactivity of anti-platelet monoclonal antibodies." dans: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 377-82, (1997) (PubMed).

  • Antigène
    CD41, CD61 (CD41,CD61)
    Abstract
    CD41, CD61 Produits
    Sujet
    CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation.,platelet GPIIb, Integrin alpha-IIb, GPalpha IIb, GPIIb, GT, GP3A, platelet GPIIIa
Vous êtes ici:
Support technique