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CD72 anticorps

CD72 Reactivité: Humain FACS, IP Hôte: Souris Monoclonal 3F3 unconjugated
N° du produit ABIN94227
  • Antigène Voir toutes CD72 Anticorps
    CD72 (CD72 Molecule (CD72))
    Reactivité
    • 46
    • 19
    • 1
    Humain
    Hôte
    • 37
    • 20
    • 1
    Souris
    Clonalité
    • 37
    • 21
    Monoclonal
    Conjugué
    • 25
    • 8
    • 7
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD72 est non-conjugé
    Application
    • 29
    • 24
    • 22
    • 8
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP)
    Specificité
    The mouse monoclonal antibody 3F3 recognizes an extracellular epitope of CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family). CD72 is a pan-B cell marker expressed throughout the B lymphocytes diferentiation with the exception of plasma cells, it is also present on follicular dendritic cells.
    Réactivité croisée (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    Normal human lymphocytes from a lymph node.
    Clone
    3F3
    Isotype
    IgG2b
  • Indications d'application
    Flow cytometry: Recommended dilution: 1 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Mizrahi, Markel, Porgador, Bushkin, Mandelboim: "CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72." dans: PLoS ONE, Vol. 2, Issue 9, pp. e818, (2007) (PubMed).

  • Antigène
    CD72 (CD72 Molecule (CD72))
    Autre désignation
    CD72 (CD72 Produits)
    Synonymes
    anticorps CD72c, anticorps Ly-19, anticorps Ly-32, anticorps Ly-m19, anticorps Lyb-2, anticorps CD72b, anticorps LYB2, anticorps CD72 antigen, anticorps CD72 molecule, anticorps Cd72, anticorps CD72
    Sujet
    CD72 Molecule,CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.,LYB2
    ID gène
    971
    UniProt
    P21854
    Pathways
    BCR Signaling
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