DAXX anticorps (AA 558-740)

N° du produit ABIN94302

Cet anticorps anti-DAXX est un anticorps Souris Monoclonal détectant DAXX dans WB et ICC. Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour DAXX anticorps (AA 558-740) (ABIN94302)

Antigène: DAXX (Death-Domain Associated Protein (DAXX))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DAXX est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Clone: DAXX-01

Détail du produit anti-DAXX anticorps

Épitope: AA 558-740

Fonction: Anti-DAXX Purified

Specificité: The mouse monoclonal antibody DAXX-01 recognizes Daxx, a cytoplasmic death domain containing protein mainly expressed in fetal and adult human and mouse tissue.

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Recombinant C-terminal part (aa 558-740) of human Daxx.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-DAXX (ABIN94302)

Leal-Sanchez, Couzinet, Rossin, Abdel-Sater, Chakrabandhu, Luci, Anjuere, Stebe, Hancock, Hueber: "Requirement for Daxx in mature T-cell proliferation and activation." dans: Cell death and differentiation, Vol. 14, Issue 4, pp. 795-806, (2007) (PubMed).

Détails sur DAXX

Antigène: DAXX (Death-Domain Associated Protein (DAXX))

Autre désignation: DAXX

Sujet: Death domain associated protein,Daxx is an apoptosis-modulating death domain-associated protein with functions in transcriptional regulation. Daxx functions both in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1).,DAP6, EAP1, BING2

ID gène: 1616

UniProt: Q9UER7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway