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GFAP anticorps

GFAP Reactivité: Humain, Porc WB, IHC (p), ICC, IHC (fro) Hôte: Souris Monoclonal GF-02 unconjugated
N° du produit ABIN94316
  • Antigène Voir toutes GFAP Anticorps
    GFAP (Glial Fibrillary Acidic Protein (GFAP))
    Reactivité
    • 297
    • 177
    • 170
    • 53
    • 53
    • 37
    • 34
    • 13
    • 13
    • 11
    • 11
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Porc
    Hôte
    • 194
    • 143
    • 12
    • 3
    • 2
    • 1
    Souris
    Clonalité
    • 195
    • 160
    Monoclonal
    Conjugué
    • 166
    • 29
    • 25
    • 19
    • 13
    • 9
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Cet anticorp GFAP est non-conjugé
    Application
    • 287
    • 129
    • 101
    • 87
    • 74
    • 62
    • 45
    • 30
    • 26
    • 26
    • 25
    • 22
    • 13
    • 8
    • 8
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    The mouse monoclonal antibody GF-02 exclusively reacts with intact GFAP molecules. GFAP is the principal marker of astroglial cells in the central nervous system, it is specifically expressed in satellite cells in peripheral ganglia and in non myelinating Schwann cells in peripheral nerves. The GFAP protein runs on gels at ~55 kDa protein, usually associated with lower Mw bands which are thought to be proteolytic fragments and alternate transcripts from the single gene.
    Réactivité croisée (Details)
    Human, Porcine
    Purification
    Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    Pellet of porcine brain cold-stable proteins after depolymerization of microtubules.
    Clone
    GF-02
    Isotype
    IgM
    Top Product
    Discover our top product GFAP Anticorps primaire
  • Indications d'application
    Western blotting: Recommended dilution: 1-2 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Porchet, Probst, Bouras, Dráberová, Dráber, Riederer: "Analysis of glial acidic fibrillary protein in the human entorhinal cortex during aging and in Alzheimer's disease." dans: Proteomics, Vol. 3, Issue 8, pp. 1476-85, (2003) (PubMed).

  • Antigène
    GFAP (Glial Fibrillary Acidic Protein (GFAP))
    Autre désignation
    GFAP (GFAP Produits)
    Synonymes
    anticorps GFAP, anticorps AI836096, anticorps cb345, anticorps etID36982.3, anticorps gfapl, anticorps wu:fb34h11, anticorps wu:fk42c12, anticorps xx:af506734, anticorps zgc:110485, anticorps glial fibrillary acidic protein, anticorps GFAP, anticorps LOC100136168, anticorps gfap, anticorps Gfap
    Sujet
    Glial fibrillary acidic proteinprovided,GFAP (glial fibrillary acidic protein) was discovered by Bignami et al. (1972) as a major fibrous protein of multiple sclerosis plaques. It was subsequently found to be a member of the 10 nm or intermediate filament protein family, specifically the intermediate filament protein family class III, which also includes peripherin, desmin and vimentin. GFAP is heavily, and specifically, expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In addition, neural stem cells frequently strongly express GFAP. It is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. Although its function is not fully understood, GFAP protein is probably involved in controlling the shape and movement of astrocytes. The protein probably also plays a significant role in the interactions of astrocytes with other cells, which are required for the formation and maintenance of the insulating layer (myelin) that covers nerve cells. Additionally, GFAP protein may assist in maintaining the protective barrier that allows only certain substances to pass between blood vessels and the brain (blood-brain barrier).In adults, GFAP levels increase as a result of the proliferation of astrocytes that occurs in a response to a variety of physical, chemical and etiological insults, including Alzheimer’,s disease, epilepsy and multiple sclerosis.Antibodies to GFAP are therefore very useful as markers of astrocytic cells and neural stem cells and for distinguishing of neoplasms of astrocytic origin from other neoplasms in the central nervous system. Finally, Alexander's disease was recently shown to be caused by point mutations in protein coding region of the GFAP gene (Brenner et al., 2001). All forms of Alexander disease are characterized by the presence of Rosenthal fibers, which are GFAP containing cytoplasmic inclusions found in astrocytes.,GFAP, ALXDRD
    ID gène
    2670
    UniProt
    P14136
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