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HLA-DR1 anticorps

HLA-DR1 Reactivité: Humain FACS, ELISA, WB Hôte: Souris Monoclonal MEM-267 unconjugated
N° du produit ABIN94350
  • Antigène Tous les produits HLA-DR1
    HLA-DR1 (MHC Class II HLA-DR1 (HLA-DR1))
    Reactivité
    Humain
    Hôte
    • 2
    Souris
    Clonalité
    • 2
    Monoclonal
    Conjugué
    • 2
    Cet anticorp HLA-DR1 est non-conjugé
    Application
    Flow Cytometry (FACS), ELISA, Western Blotting (WB)
    Specificité
    The antibody MEM-267 specifically binds extracellularly to the empty but not peptide-loaded form of HLA-DR1. DR is the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC, dendritic cells, B lymphocytes, monocytes, macrophages).
    Réactivité croisée (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    Purified, insoluble DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.
    Clone
    MEM-267
    Isotype
    IgG2b
  • Indications d'application
    Flow cytometry: The antibody MEM-267 stains immature dendritic cells that express empty cell surface MHC molecules, but not cells that express predominantly peptide loaded forms.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Antigène
    HLA-DR1 (MHC Class II HLA-DR1 (HLA-DR1))
    Autre désignation
    HLA-DR1 (HLA-DR1 Produits)
    Sujet
    HLA-DR1 belongs to the HLA class II beta chain paralogues. The MHC Class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. MHC Class II molecules are expressed in antigen presenting cells (APC). The beta chain is approximately 26-28 kDa. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.
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