PD-1 anticorps

N° du produit ABIN951270

Cet anticorps anti-PD-1 est un anticorps Hamster Monoclonal détectant PD-1 dans FACS. Adapté pour Souris.

Aperçu rapide pour PD-1 anticorps (ABIN951270)

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reactivité: Souris

Hôte: Hamster

Clonalité: Monoclonal

Conjugué: Cet anticorp PD-1 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: J43

Détail du produit anti-PD-1 anticorps

Specificité: This Monoclonal Antibody reacts with Mouse PD-1 (Programmed Death-1).

Purification: Protein G Chromatography

Immunogène: PD-1 cDNA transfectant. Donor: mouse ascites fluid. Fusion Partner: Mouse myeloma P3U1.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PD-1

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Autre désignation: CD279 / PD1

Sujet: CD279 is 50-55kD membrane protein which is a member of the CD28 family, and functions mainly as a negative regulator of T-cell activation. CD279 has two specific ligands, CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance. CD279 is inducibly expressed by T-cells, B-cells, NK-T-cells and monocytes upon activation. Loss of CD279 function has been associated with a number of autoimmune diseases, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis. Recent studies suggest that CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion.Synonyms: PDCD1, Programmed cell death protein 1, Protein PD-1, hPD-1

ID gène: 18566

NCBI Accession: NP_032824

UniProt: Q02242

Pathways: Cancer Immune Checkpoints