Cyclin T1 anticorps (Middle Region)

N° du produit ABIN951765

Cet anticorps anti-Cyclin T1 est un anticorps Lapin Polyclonal détectant Cyclin T1 dans WB, FACS, IHC (p) et EIA. Adapté pour Humain et Souris. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour Cyclin T1 anticorps (Middle Region) (ABIN951765)

Antigène: Cyclin T1 (CCNT1)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin T1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-Cyclin T1 anticorps

Épitope: AA 256-285, Middle Region

Specificité: This antibody reacts to CCNT1.

Réactivité croisée (Details): Species reactivity (tested):Human and Mouse.

Purification: Affinity chromatography on Protein A

Immunogène: KLH conjugated synthetic peptide between 256-285 amino acids from the Central region of human CCNT1

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-Cyclin T1 (ABIN951765)

Kapasi, Clark, Tran, Spector: "Recruitment of cdk9 to the immediate-early viral transcriptosomes during human cytomegalovirus infection requires efficient binding to cyclin T1, a threshold level of IE2 86, and active transcription." dans: Journal of virology, Vol. 83, Issue 11, pp. 5904-17, (2009) (PubMed).

Détails sur Cyclin T1

Antigène: Cyclin T1 (CCNT1)

Autre désignation: Cyclin T1

Sujet: CCNT1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.Synonyms: CCNT1, CycT1, Cyclin-T, Cyclin-T1

Poids moléculaire: 80685 Da

ID gène: 904

NCBI Accession: NP_001231