GPC2 anticorps (N-Term)

N° du produit ABIN952586

L’anticorps Lapin Polyclonal anti-GPC2 a été validé pour WB et EIA. Il convient pour détecter GPC2 dans des échantillons de Humain et Souris.

Aperçu rapide pour GPC2 anticorps (N-Term) (ABIN952586)

Antigène: GPC2 (Glypican 2 (GPC2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPC2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-GPC2 anticorps

Épitope: AA 136-165, N-Term

Specificité: Recognizes GPC2 (N-term).

Purification: Protein A column followed by peptide Affinity purification

Immunogène: KLH conjugated synthetic peptide between 136-165 amino acids from the N-terminal region of Human GPC2 (NP_689955.1) Genename: GPC2

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur GPC2

Antigène: GPC2 (Glypican 2 (GPC2))

Autre désignation: GPC2

Sujet: The glypicans (GPC) constitute a family of heparan sulfate proteoglycans that are attached to the cell surface by a lycosylphosphatidylinositol (GPI) anchor. Six members of this family have been identified in mammals (GPC1-GPC6). All glypican core proteins contain an N-terminal signal peptide, a large globular cysteine rich domain (CRD) with 14 invariant cysteine residues, a stalklike region containing the heparan sulfate attachment sites, and a C-terminal GPI attachment site. Based on the degree of their amino acid sequence similarity, two subfamilies of glypicans have been defined. One subfamily (sharing from 35-63 % sequence homology) includes GPC1, 2, 4, and 6, while the second subfamily (sharing 54 % sequence identity) includes GPC3 and 5. Proteins between the two subfamilies also share 17-25 % sequence similarity (1-4). Glypicans are widely expressed in adult and fetal tissues. During embryonic development, the expression level of the various glypicans changes in a stage and tissue specific manner. GPC2, also known as cerebroglycan, is primarily expressed in developing neuronal tissues including the brain, spinal cord, dorsal root ganglia, and cranial nerves. It is found on the tracts of actively growing axons (5). Cell surface GPC2 binds midkine, indicating midkine GPC2 interaction may participate in neuronal cell migration and neurite outgrowth (6).Synonyms: Glypican-2

ID gène: 221914

NCBI Accession: NP_689955

Pathways: Glycosaminoglycan Metabolic Process