Haptoglobin anticorps (Middle Region)

N° du produit ABIN952678

Cet anticorps Lapin Polyclonal détecte spécifiquement Haptoglobin dans WB, FACS, IF, IHC (p) et EIA. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour Haptoglobin anticorps (Middle Region) (ABIN952678)

Antigène: Haptoglobin (HP)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Haptoglobin est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-Haptoglobin anticorps

Épitope: AA 299-326, Middle Region

Specificité: This antibody recognizes Human Haptoglobin (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogène: KLH conjugated synthetic peptide between 299-326 amino acids from the Central region of Human Haptoglobin Genename: HP

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-Haptoglobin (ABIN952678)

Higham, Baker, Jackson, Shah, Lea, Singh: "Dysregulation of the CD163-Haptoglobin Axis in the Airways of COPD Patients." dans: Cells, Vol. 11, Issue 1, (2022) (PubMed).

Détails sur Haptoglobin

Antigène: Haptoglobin (HP)

Autre désignation: Haptoglobin

Sujet: This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 45205 Da

ID gène: 3240

NCBI Accession: NP_001119574

Pathways: Transition Metal Ion Homeostasis