Integrin beta 7 anticorps (C-Term)

N° du produit ABIN952915

Cet anticorps Lapin Polyclonal détecte spécifiquement Integrin beta 7 dans WB et EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour Integrin beta 7 anticorps (C-Term) (ABIN952915)

Antigène: Integrin beta 7 (ITGB7)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Integrin beta 7 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-Integrin beta 7 anticorps

Épitope: AA 736-765, C-Term

Specificité: This antibody recognizes Human Integrin beta-7 (C-term).

Purification: Protein A column, followed by peptide affinity purification

Immunogène: KLH conjugated synthetic peptide between 736-765 amino acids from the C-terminal region of Human Integrin beta-7

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Integrin beta 7

Antigène: Integrin beta 7 (ITGB7)

Autre désignation: Integrin beta-7

Sujet: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.Synonyms: ITGB7, Integrin alpha 4 beta 7, Integrin beta-P, LPAM-1, LPAM1, M290 IEL antigen

Poids moléculaire: 86903 Da

ID gène: 3695

NCBI Accession: NP_000880

Pathways: Integrin Complex