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LIN28A anticorps (Middle Region)

LIN28A Reactivité: Humain, Souris WB, FACS, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN953174
  • Antigène Voir toutes LIN28A Anticorps
    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
    Épitope
    • 15
    • 9
    • 9
    • 7
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 115-147, Middle Region
    Reactivité
    • 102
    • 28
    • 21
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 81
    • 23
    Lapin
    Clonalité
    • 74
    • 30
    Polyclonal
    Conjugué
    • 49
    • 9
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LIN28A est non-conjugé
    Application
    • 68
    • 41
    • 30
    • 22
    • 16
    • 14
    • 13
    • 13
    • 9
    • 9
    • 7
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody recognizes Human and Mouse LIN28A (Center).
    Purification
    Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
    Immunogène
    KLH conjugated synthetic peptide between 115-147 amino acids from the Central region of human LIN28A
    Isotype
    Ig Fraction
    Top Product
    Discover our top product LIN28A Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS containing 0.09 % (W/V) Sodium Azide as preservative
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
    Autre désignation
    LIN28 (LIN28A Produits)
    Synonymes
    anticorps CSDD1, anticorps LIN-28, anticorps LIN28, anticorps ZCCHC1, anticorps lin-28A, anticorps AL024421, anticorps ENSMUSG00000070700, anticorps Gm10299, anticorps Lin-28, anticorps Lin28, anticorps Tex17, anticorps csdd1, anticorps lin-28, anticorps lin28, anticorps zcchc1, anticorps sb:cb650, anticorps zgc:55584, anticorps RGD1566408, anticorps lin-28 homolog A, anticorps lin-28 homolog A (C. elegans), anticorps lin-28 homolog A S homeolog, anticorps LIN28A, anticorps Lin28a, anticorps lin28a.S, anticorps lin28a
    Sujet
    Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.Synonyms: CSDD1, LIN-28, LIN28A, Lin-28 homolog A, ZCCHC1
    Poids moléculaire
    22743 Da
    ID gène
    79727
    NCBI Accession
    NP_078950
    Pathways
    Stem Cell Maintenance
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